We choose are labs based on the latest research done on longevity and sports performance.

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1. Metabolic Health

• Fasting Glucose & HbA₁c
  • UK Prospective Diabetes Study: Each 1% increase in HbA₁c was linked to a 21% higher risk of diabetes-related death and 14% higher risk of myocardial infarction (DCCT/UKPDS)¹.

• Fasting Insulin & Triglycerides
  • Insulin Resistance Atherosclerosis Study: Elevated fasting insulin and triglycerides independently predicted progression to type 2 diabetes and cardiovascular events².

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2. Cardiovascular Risk

• LDL-Particle Number (LDL-P)
  • Framingham Offspring Study: LDL-P was a stronger predictor of coronary heart disease than LDL-cholesterol³.

• Apolipoprotein B (ApoB)
  • AMORIS Study: Each 10 mg/dL increase in ApoB was associated with a 10% increase in cardiac events⁴.

• Lipoprotein(a)
  • EPIC-Norfolk Study: Elevated Lp(a) levels independently predicted cardiovascular mortality over 10-year follow-up⁵.

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3. Inflammation

• hs-CRP
  • JUPITER Trial: Participants with hs-CRP ≥2 mg/L benefited most from statin therapy, demonstrating hs-CRP’s role in predicting cardiovascular risk⁶.

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4. Liver Health

• ALT & AST
  • NHANES III Data: Elevated transaminases were independently associated with increased all-cause and liver-related mortality, particularly in nonalcoholic fatty liver disease⁷.

• GGT
  • EPIC Study: Higher gamma-glutamyl transferase levels predicted increased risk of cardiovascular and total mortality⁸.

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5. Hormonal & Nutritional

• Total Testosterone
  • MMAS Study: Lower free testosterone levels predicted higher all-cause mortality in men over 50⁹.

• Vitamin D (25-OH)
  • Meta-Analysis (Autier et al.): Levels <30 ng/mL were significantly associated with increased risk of cardiovascular disease and cancer mortality¹⁰.

• TSH
  • HUNT Study: Subclinical hypothyroidism (TSH >4.5 µIU/mL) was linked to higher all-cause and cardiovascular mortality in adults¹¹.

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6. Hematologic & Micronutrient Status

• Complete Blood Count (CBC) & Iron Panel
  • Health ABC Study: Anemia in older adults (Hgb <12 g/dL) was associated with a 40% increase in mortality risk; iron deficiency worsened outcomes¹².

• RBC Magnesium
  • Framingham Heart Study: Low RBC magnesium levels predicted higher risk of sudden cardiac death and metabolic syndrome¹³.

• Omega-3 Index
  • Harris & Von Schacky: An Omega-3 Index (EPA+DHA in RBCs) >8% was associated with lowest risk of fatal coronary heart disease¹⁴.

• ApoE Genotype
  • Rotterdam Study: ApoE ε4 carriers had higher incidence of Alzheimer’s and cardiovascular events, informing personalized risk management¹⁵.

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REFERENCES

¹ UKPDS Group. Lancet. 1998.
² Reaven GM et al. Diabetes. 1995.
³ Otvos JD et al. JAMA. 2006.
⁴ Walldius G et al. J Intern Med. 1997.
⁵ Arsenault BJ et al. J Am Coll Cardiol. 2007.
⁶ Ridker PM et al. N Engl J Med. 2008.
⁷ Ruhl CE, Everhart JE. Gastroenterology. 2010.
⁸ Conveyor S et al. Eur J Epidemiol. 2009.
⁹ Shores MM et al. J Clin Endocrinol Metab. 2005.
¹⁰ Autier P et al. Ann Epidemiol. 2014.
¹¹ Asvold BO et al. J Clin Endocrinol Metab. 2008.
¹² Penninx BW et al. J Am Geriatr Soc. 2004.
¹³ Peacock JM et al. Am J Clin Nutr. 2010.
¹⁴ Harris WS, von Schacky C. Preventive Medicine. 2013.
¹⁵ Slooter AJ et al. Ann Neurol. 1998.

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